1 Foundation domain

Energy & Metabolic Resilience

Your skin's ability to power its own repair. When cellular energy declines, every other repair process slows with it.

You might recognise this as

Skin that looks flat or dull even when you're not tired. Slower recovery after cleansing or environmental stress.

Energy & Metabolic Resilience

The biology

Why energy is the foundation of everything

Barrier recovery, collagen synthesis, DNA repair — all of these require ATP generated by mitochondria. As mitochondrial efficiency and NAD+ availability decline with age, repair slows across every domain.

In younger skin

In younger skin

Fast, efficient repair

Mitochondria run at high capacity. NAD+ is abundant. Skin recovers quickly after daily stress.

With age and stress

With age & stress

Slower, less complete recovery

Mitochondrial efficiency declines. NAD+ falls. Repair becomes slower — damage accumulates faster than it can be corrected.

Key actives

How Evolve supports this domain

These ingredients work together to support mitochondrial efficiency, reduce oxidative burden, and maintain cellular recycling pathways.

NAD+ precursor · energy metabolism

Niacinamide

A precursor of NAD+, niacinamide supports cellular energy metabolism and DNA repair. It works upstream — helping maintain the energy currency all repair processes depend on.

In brief

NAD+ is essential for mitochondrial energy production and DNA repair. Studies show niacinamide can restore NAD+ levels in ageing cells and support collagen synthesis in older fibroblasts.

Niacinamide

Antioxidant · collagen support

Vitamin C

One of skin's most important antioxidants, Vitamin C neutralises the free radicals generated by UV exposure and environmental stress — the same oxidative damage that depletes cellular energy reserves and slows mitochondrial function. It also acts as an essential co-factor in collagen synthesis, making it a crossover active that supports both the energy and structural domains.

In brief

Vitamin C is required for the hydroxylation of proline and lysine in collagen synthesis — without it, collagen cannot be properly formed. As an antioxidant, it has been shown to significantly reduce oxidative stress in skin cells, helping to preserve the mitochondrial function that underpins all repair processes.

Vitamin C

Stress protection · cellular stability

Extremolytes

Extremolytes are natural compounds produced by microorganisms that have evolved to survive extreme environments — intense heat, cold, UV radiation and osmotic stress. Applied topically, they form a protective shield around skin cells, stabilising cellular structures under stress and reducing the energy cost of environmental defence. When skin spends less energy managing stress, more is available for repair.

In brief

Clinical studies on ectoin and related extremolytes have demonstrated significant protective effects on cellular membranes and proteins under oxidative and thermal stress. By reducing the cellular burden of environmental damage, extremolytes help preserve the energy reserves skin needs for its own repair processes.

Extremolytes

Questions

Frequently asked

Topical formulations can't alter systemic energy metabolism, but they can support the local biological environment of the skin — reducing oxidative burden, supporting NAD+ precursor availability, and maintaining the conditions repair processes need to function well.
Topical formulations can't alter systemic energy metabolism, but they can support the local biological environment of the skin — reducing oxidative burden, supporting NAD+ precursor availability, and maintaining the conditions repair processes need to function well.
Topical formulations can't alter systemic energy metabolism, but they can support the local biological environment of the skin — reducing oxidative burden, supporting NAD+ precursor availability, and maintaining the conditions repair processes need to function well.

Find your routine

Not sure which products are most relevant to your skin? Take the quiz and we'll connect your concerns to the biological systems at work.

Take the skin longevity quiz